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For your reference, we have included the original job posting below.
Institute Associate Scientist III, Analytical Chemistry
Job Number:
38804932
Company Name:
MD Anderson Cancer Center
Job Location:
Houston, TX US
Job Categories:
Research Healthcare & Medical
Institute Associate Scientist III, Analytical Chemistry
Institute Associate Scientist III, Analytical Chemistry Job Category: Research Sub Category: Research Department: Applied Cancer Science Inst Salary: Employment Status: Full Time Work Week: Mon-Fri Shift: Days
KEY FUNCTIONS
1. Under minimal supervision contribute to project activities through laboratory experiments. 2. Help to establish, and validate mechanistic and functional biochemical and/or cell-based studies for evaluating novel therapeutic targets. 3. Independently design and utilize novel in vivo mouse xenograft and syngeneic models to support target validation efforts. 4. Dose animals and analyze the outcome of pharmacokinetic, pharmacodynamic and efficacy studies utilizing subcutaneous and orthotopic murine oncology models. 5. Utilize non-invasive imaging to monitor model progression upon therapeutic intervention. 6. Assist in the utilization of in vivo models to advance biomarker discovery, understand target mechanism of action and provide target validation to establish target relevance in a defined responder population. 7. Execute standard synthetic chemistry manipulations, analyze the outcome and suggest alternative approaches. 8. Execute standard in vitro and cellular screening protocols of novel therapeutic agents and troubleshoots issues, under supervision optimize assay protocols. 9. Interact closely with other research staff across institutional functional teams. 10. Responsible for providing analytical and separation sciences support to the small molecule drug discovery programs of the Institute for Applied Cancer Sciences 11. Oversee the operation of multiple LC/MS systems and preparative HPLC/MS systems. 12. Responsible for setting up and the daily operation of the mass triggered preparative HPLC instrument. 13. Maintain instrumentation in good working order, and perform basic maintenance of equipment, obtaining prompt service from external sources as and when required. 14. Interface with medicinal chemists to ensure their mass spectrometry and purification needs are met. 15. Hands-on research towards efficiency improvements, new instrumentation, and novel techniques is encouraged. 16. Employ safe laboratory practices. 17. Maintain research records and laboratory notes.
CORE COMPETENCIES
1. Self Motivation (Transitional): Set high standards of performance; pursue goals with energy and persistence; drive for results and achievement. Demonstrate a personal sense of urgency in getting results. Use personal and management standards to complete assignments. Seek to influence standards with proven business practices. Improve own performance by making specific changes in system or work methods.
2. Technical/Functional Expertise (Independent Contributor): Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others. Apply basic technical/functional knowledge to complete work. Meet essential position requirements. Seek experiences and knowledge in technical/functional areas to gain additional expertise. Troubleshoot systems/processes effectively.
3. Analytical Thinking (Independent Contributor): Gather relevant information systematically; break down problems into simple components; make sound decisions. Recognize simple cause and effect relationships. Diagnose problems by breaking them down into simple tasks or activities. Identify relationships among a few parts of a problem. Scan own knowledge and experience base to determine potential solutions.
4. Team with Others (Independent Contributor): Encourage collaboration and input from all team members; value the contributions of all team members, and those beyond team; balance individual and team goals. Support and show respect to team members. Recognize how individual actions affect the team. Model team qualities, i.e. respect helpfulness and coping. Support team decisions once they are made and help to implement. EDUCATION
Required: Bachelor's degree in Science or related field from an accredited university
Preferred: Bachelor's degree in chemistry or Master's degree in a related field, such as analytical chemistry
EXPERIENCE
Required: With Bachelor's degree, three years of relevant research experience. With Master's degree, at least one year of required experience.
Preferred: An expert in separation science and analytical chemical analysis of small molecules. Experience in the operation of preparative and analytical HPLC/UPLC instruments, and a strong background in mass spectrometry. Previous experience in the operation of mass triggered preparative HPLC instruments. Experience of optimizing HPLC equipment and ensuring its efficient operation, minimizing delays and improving efficiency. Demonstrated team-worker who possesses excellent problem solving capabilities and can work efficiently with minimal supervision.
WORKING CONDITIONS
Laboratory environment
This position requires: Working in Office Environment ____No __X_ Yes Working in Patient Care Unit (e.g. Nursing unit; outpatient clinic) _X_ No ____ Yes Exposure to human/animal blood, body fluids, or tissues _X_No __ _ Yes Exposure to harmful chemicals ____No __X_ Yes Exposure to radiation _X_ No ____ Yes
