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Title: Clinical Research Associate / CRA / Sr. CRA Houston* Location: USATexasHouston Other Locations: Quintiles pioneered the idea of helping pharma companies ...
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Institute Associate Scientist III, Target Validation
Job Number:
38806155
Company Name:
MD Anderson Cancer Center
Job Location:
Houston, TX US
Job Categories:
Research Healthcare & Medical
Institute Associate Scientist III, Target Validation
Institute Associate Scientist III, Target Validation Job Category: Research Sub Category: Research Department: Applied Cancer Science Inst Salary: Employment Status: Full Time Work Week: Mon-Fri Shift: Days
MISSION STATEMENT The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public. SUMMARY
The Institute Assistant Scientist III participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients.
KEY FUNCTIONS
1. Under minimal supervision contribute to project activities through laboratory experiments. 2. Help establish and validate mechanistic and functional cell based studies for evaluating novel therapeutic targets. 3. Independently design and utilize novel in vivo mouse xenograft and allograft models. 4. Dose animals and analyze the outcome of pharmacokinetic, pharmacodynamic and efficacy studies. 5. Utilize non-invasive imaging. 6. Assist in utilization of in vivo models. 7. Contribute to project team. 8. Employ safe lab practices. 9. Maintain research records and laboratory notes. 10. Perform common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines. 11. Demonstrate knowledge of complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors. 12. Utilize common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies. 13. Apply vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer. 14. Develop and utilize molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and/or functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays 15. Utilize siRNA, inducible shRNA, dominant negative methods, and small molecule inhibitors to validate targets and biomarkers. EDUCATION
Required: Bachelor's degree in Science or related field from an accredited university
Preferred: Bachelor's degree in biology or molecular biology Master's degree in a related field, such as biology or molecular biology
EXPERIENCE
Required: With Bachelor's degree, three years of relevant research experience. With Master's degree, one year of relevant experience is required.
Preferred: Experience with common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines; experience with complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors. Common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies. Experience (or willingness to work) with vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer; previous experience dosing animals. Experience developing and utilizing molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and/or functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays are strongly preferred.
Experience using siRNA, inducible shRNA, dominant negative methods to validate targets; as well as experience with utilizing small molecule inhibitors for target and biomarker validation are preferred.
A collaborative attitude is essential for this position.
