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Institute Associate Scientist IV, Target Validation
Job Number:
38804944
Company Name:
MD Anderson Cancer Center
Job Location:
Houston, TX US
Job Categories:
Research Healthcare & Medical
Institute Associate Scientist IV, Target Validation
Institute Associate Scientist IV, Target Validation Job Category: Research Sub Category: Research Department: Applied Cancer Science Inst Salary: Employment Status: Full Time Work Week: Mon-Fri Shift: Days
MISSION STATEMENT The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees and the public.
SUMMARY
The Institute Assistant Scientist IV participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients.
CORE VALUES
Caring Behaviors
' Courtesy: Is respectful and courteous to each other at all times ' Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; Is sensitive to the concerns of our patients and our co-workers
Integrity Behaviors
' Reliability: Communicates frequently, honestly and openly ' Accountability: Holds self and others accountable for practicing our values
Discovery Behaviors
' Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas ' Safety: Notices a safety concern and brings it to someone's attention; Models safe behaviors (wears badge, washes hands, keeps work area clean and orderly); maintains documents in accordance with document retention standards ' Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so ' Risk: Mitigates risk to institution through sound business practices
KEY FUNCTIONS
1. Independently propose innovative solutions to research projects, and contribute to project goals through laboratory experiments. 2. Assist in the application and development of cutting edge tools and methodologies to analyze data generated by various studies. 3. Assist in the integration of data to identify genes/pathways pertinent to tumor development and treatment. 4. Work closely with research team to identify and recommend opportunities leading to the discovery of tumor related genes/pathways to further advance scientific discovery and clinical therapeutic drug development. 5. Propose new target molecules, design synthetic routes and execute the synthesis thereof. 6. Designs and optimizes alternative assay formats and improves assay performance. 7. Adapt to new technologies and find solutions to related program studies. 8. Perform common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines. 9. Demonstrate knowledge of complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors. 10. Utilize common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies. 11. Apply vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer. 12. Develop and utilize molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and/or functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays 13. Utilize siRNA, inducible shRNA, dominant negative methods, and small molecule inhibitors to validate targets and biomarkers.
CORE COMPETENCIES
1. Self Motivation (Independent Contributor): Set high standards of performance; pursue goals with energy and persistence; drive for results and achievement. Use standards set by management. Take ownership for actions. Continually meet department goals. Demonstrate a personal sense of urgency in getting results. Use personal and management standards to complete assignments.
2. Technical/Functional Expertise (Independent Contributor): Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others. Apply basic technical/functional knowledge to complete work. Meet essential position requirements. Seek experiences and knowledge in technical/functional areas to gain additional expertise. Troubleshoot systems/processes effectively.
3. Analytical Thinking (Independent Contributor): Gather relevant information systematically; break down problems into simple components; make sound decisions. Recognize simple cause and effect relationships. Diagnose problems by breaking them down into simple tasks or activities. Identify relationships among a few parts of a problem. Scan own knowledge and experience base to determine potential solutions.
4. Team with Others (Independent Contributor): Encourage collaboration and input from all team members; value the contributions of all team members, and those beyond team; balance individual and team goals. Support and show respect to team members. Recognize how individual actions affect the team. Model team qualities, i.e. respect helpfulness and coping. Support team decisions once they are made and help to implement. EDUCATION
Required: Bachelor's degree in Science or related field from an accredited university
Preferred: Bachelor's degree in biology or molecular biology Master's degree in a related field, such as biology or molecular biology
EXPERIENCE
Required: With Bachelor's degree, five years of relevant research experience. With Master's degree, three years of relevant experience is required.
Preferred: Experience with common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines; experience with complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors; common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (ie site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies; experience (or willingness to work) with vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer; previous experience dosing animals; and, experience developing and utilizing molecular (ie. Immunofluoresence, live imaging, ELISA, Western, etc.) and/or functional (ie soft agar, migration, invasion, proliferation, etc.) cell based assays are strongly preferred.
Experience using siRNA, inducible shRNA, dominant negative methods to validate targets; as well as experience with utilizing small molecule inhibitors for target and biomarker validation are preferred.
The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.
