I am looking for an industrial position as Analytical Chemist utilizing a wide range of techniques in separation science, with a strong academic background, with 4+-work experience, and with the ability to work in a cross-field team environment
Skills
Instrumental analysis: method development, troubleshooting, personnel training
Analysis of environmental samples, multi-component organic mixtures, food samples
Spectroscopic identification of small-to-medium size organic molecules
Natural products chemistry
Cell culture techniques: toxicology, hepatoprotective activity, virology, monoclonal antibody
Computational chemistry: ab initio calculations
Drug design: quantitative structure-activity relationship studies
Professional Experience
••••• Lab Technician (internship, •••••/••••• – present)
Rural Technologies, Inc. •••••), Brookings, SD
Contact Person: Kysa Gilkerson, MS, Director of Laboratory Operation
Position Responsibilities
Lead cell biology related assays, such as animal virology (virus isolation, serum neutralization), hybridoma cell maintenance and monoclonal antibody generation.
••••• Research Assistant (•••••/••••• - •••••/•••••)•••••
Institute of Molecular and Isotope Technology •••••)
Dept. of Organic Mass Spectrometry & Chromatography, Cluj-Napoca, Romania
•••••Head of Department and Contact Person: Dr. Zaharia Moldovan
Position Responsibilities
As part of the gas-chromatography team I was involved in research projects and routine analysis that required numerous method development, troubleshooting, and interaction with customers. I was also engaged in personnel training and consulting on new GC and GC/MS (hp and Chrompack) for various companies. Main research projects: GC analysis of sulphides; Determination of response factors for permanent gases in H2 eluent; Carbon monoxide trace analysis; Analysis of noble gases; Caffeine determination in soluble and ground coffee; Trifluraline quantization from the pesticide Triflurex; Petroleum products determination in contaminated soil; Lindan determination from anti-parasite creams; Identification of organic compounds in the air; Organo-chlorinated pesticides determination from food samples.
Education
••••• Ph.D. in Chemistry (•••••/••••• - present)
Graduate Teaching Assistant•••••
South Dakota State University •••••), Dept. Chemistry & Bioch., Brookings, SD
Advisor: Dr. Fathi T. Halaweish
G.P.A: •••••/•••••
Award: The Joseph F. Nelson Graduate Scholarship (Top Award for SDSU student, •••••)
Doctorate Project “Cucurbitacins Hepatoprotective Activity”
Some triterpene derivatives were generated by isolation from Cucurbita texana and Citrullus lanatus and by semi-synthesis. Cucurbitacins are well known for their hepatoprotective, anti-inflammatory and many other activities in the folk medicine. To evaluate the effect of different functional groups on cytotoxicity, in vitro cytotoxicity and lipophilicity were measured and their correlation studied. Both estimated and RP-HPLC measured lipophilicity values were investigated for this purpose. Cucurbitacins hepatoprotective activity was screened on two immortalized liver cell lines: hepatocytes and stellate cells, and interesting conclusion drawn. Further QSAR studies involved ab initio generated physicochemical parameters (Gamess/Linux and Gaussian/Windows). Several smaller projects have also been accomplished, such as antioxidant and anti-hyaluronidase activities, as well as investigation of differential cytotoxicity.
••••• B. S. in Research Chemistry (•••••/••••• - •••••/••••• )•••••
University "Babes-Bolyai" •••••)
Faculty of Chemistry and Chemical Engineering, Cluj-Napoca, Romania
Advisor: Dr. Iovanca Haiduc •••••)
G.P.A.: •••••/•••••
Project “Chlorine potentiometric determination from running and wastewaters”
Presentations
••••• •••••, Fathi T. Halaweish Hepatoprotective and antitumor activities of cucurbitacins. •••••rd ACS National Meeting in Orlando, FL. Medicinal Chemistry Division, April •••••
••••• •••••, Fathi T. Halaweish Cucurbitacins lipophilicity by fast gradient RP-HPLC. •••••th Midwest Regional Meeting in Columbia, MO. Analytical Chemistry Division, November •••••
••••• •••••, Fathi T. Halaweish QSAR of cucurbitacin homologues using HepG2 cells and chromatographic hydrophobicity indexes. •••••th ACS National Meeting in Anaheim, CA. Medicinal Chemistry Division, March •••••
Publications
••••• •••••, Fathi T. Halaweish “Relationship between cucurbitacins chromatographic hydrophobicity index and in vitro cytotoxicity”, J. Chromatogr., B. (recently accepted).
••••• •••••, Fathi T. Halaweish “Cucurbitacin hepatoprotective activity screening on HepG2 and HSC-T6 cell lines” (in preparation).
••••• •••••, Fathi T Halaweish, Christopher C. Chase “QSAR studies involving cucurbitacins cytotoxicity and hepatoprotective activity” (in preparation)
