PhD post-doctoral fellow in Endocrinology

QUALIFICATION OF MY RESEARCH CAREER

I was born on October •••••th, ••••• in the city of Enschede, the Netherlands. My initial research as an experimental psychologist focused on laboratory and questionnaire studies in humans. By the time I turned PhD (•••••), my interest in biomedical science had grown to a point where I decided to seek additional science training, culminating in an MSc degree in pharmacology. After moving to the United States, my research activity has been intense, but intermittent, because of visa-related procedures. I am motivated to develop my career researching obesity and associated pathology.

EDUCATION AND RESEARCH

Post-Doctoral Fellowship #2
Oct ••••• present, Apr ••••• - March •••••
Affiliation: Dept. of Medicine, University of Washingto
Mentor: Prof. David E. Cummings, MD
Activities:
- Developed two chronic surgical models to study physiology in conscious rats: double cannulations (jugular vein - small intestinal, and jugular vein - 3rd intracerebroventricular). Identified a role for the following factors in meal-related ghrelin suppression: macronutrient type, duodenum and jejunum, intestinal hyperosmolarity, peripheral neural activation, and brain insulin.
- Established mouse laboratory for round-the-clock monitoring of food and fluid intake. Used this set-up to phenotype ghrelin-receptor knockout mice and to test behavioral effects of ghrelin-receptor antagonist drugs.
- Developed several custom-made computer programs for automated analysis of meal patterns (solid and liquid food) in rodents. Software currently in use by Animal Physiology Core Facility (Prof. M.W. Schwartz, Division of Metabolism, Endocrinology and Nutrition, Dept. of Medicine, UW).
- Managed in-house breeding program to produce ghrelin-receptor knockout mice with uniform C•••••B6/J genetic background.
- Assessed of glucose counterregulation in mice lacking the ghrelin receptor.

Visiting Researcher•••••
June-August •••••
- Dept. of Biomedical Sciences, Univ. of Sheffield (host: Prof. David Grundy, PhD)
- Institute of Histology and Microscopic Anatomy, University of Antwerpen, Belgium
(host: Prof. Jean-Pierre. Timmermans, PhD)
- Dept of Pharmacology, University of Graz, Austria (host: Prof. Peter Holzer, PhD)
Activities:
- Learned to dissect rat and guinea pig enteric nervous system
- Pilot study c-Fos immunohistochemistry of myenteric plexus in fasted/ re-fed rats
- Tutored PhD student

Post-doctoral Fellowship # 1
July ••••• - July •••••
Affiliation: Weill Medical College, Cornell University, White Plains, New York.•••••
Mentor: Prof. James G. Gibbs, MD
Activities:
- Chronic infusions of satiety peptides (GRP, CCK, GLP•••••) in chronically v. cava cannulated rats and their effect on food intake
- Effects of ip CCK8 and CCK••••• on intermeal interval in rats
- Set up laboratory for round-the-clock automated food intake measurement in bombesin receptor subtype••••• knockout and wildtype mice
- Designed software for automatic analysis of mouse meal patterns, and automatically processing of food weights on digital scales by computer.

MSc Degree in Pharmacology
Sept ••••• - Nov •••••
School of Pharmacy, University of Bradford, UK
Mentor: M.E. Kelly, PhD
Activities:
- Masters thesis: Conditioned place preference and exploratory behaviour in the rat
- Side job as external lecturer at Dept. of Nursing Sciences, University of Bradford: Statistical analyses questionnaires, tutoring of PhD students, lecturing in introductory psychology for nursing science students.


PhD in Experimental Psychology•••••
•••••
University of Maastricht•••••
Mentors: Prof. Anita Jansen, PhD; Prof. Marcel van den Hout, PhD
Activities:
- Doctoral Dissertation: Pavlovian Conditioning and Binge Eating in humans
- Psychophysiologic responsivity, i.e., galvanic skin response, startle reflex, facial EMG to food-related stimuli in humans
- Pavlovian conditioning in humans of insulin and blood glucose responses
- Stroop reaction tasks to assess attentional processes related to food stimuli
- Designed and statistically validated new eating style questionnaire (item and factor analysis)

Graduate training
Physics University of Leiden
••••• ••••• completed freshman year, with honors

Psychology•••••
University of Utrecht •••••
University of Amsterdam ••••• (graduation cum laude, mentor: Prof. Nico Frijda, PhD)
University of Bologna, Italy ••••• (Erasmus fellowship; European Union student mobility program)

High School •••••
Kottenpark Atheneum-B, Enschede •••••

Miscellaneous additional training:
- Second European Summer School of Neurogastroenterology. August ••••• Haigerloch, Germany
- Visual Basic 6 programming. Westchester College Spring ••••• Valhalla, New York•••••
Visual C••••• programming, Westchester College Fall ••••• Valhalla, New York
- Certification Animal Science, Univ. of Utrecht Spring •••••
- Ethology Univ. of Utrecht Winter •••••/•••••
- Fundamentals of Biology Univ. of Utrecht Winter •••••/•••••




Publications
Peer-reviewed Papers
••••• •••••, J. (•••••) Het voordeel van de schrik. Over het onvolledige gebruik van de reflex in emotieonderzoeken. De Psycholoog •••••: ••••• •••••
••••• Merckelbach, H. & •••••, J. (•••••). Een Nederlandse Pavloviaan: J. ten Cate (••••• •••••). De Psycholoog •••••: ••••• •••••
••••• •••••, J. (•••••). Leidens Ontzet in de ethologie. Herwaardering van de dierlijke subjectiviteit. De Psycholoog •••••: ••••• •••••
••••• •••••, J. & Jansen, A. (•••••). A new scale for use in non clinical research into disinhibitive eating. Personality and Individual Differences •••••: ••••• •••••
••••• •••••, J. & Jansen, A. (•••••). Food cue reactivity in fasting and non fasting subjects. European Eating Disorders Review 4: ••••• •••••
••••• •••••, J. & Eilkes, H., Jansen, A. (•••••). Cue reactivity to food and body stimuli in restrained and unrestrained eaters. Addictive Behaviors •••••: •••••
••••• •••••, J. & Jansen, A. (•••••). Conditioned insulin and blood sugar responses in humans in relation to binge eating. Physiology and Behavior •••••: •••••
••••• •••••, J., Dworkin, B.R. & Jansen, A. (•••••). Introduction, translation and commentary to Mityushov (•••••), Conditioned reflex secretion of insulin. Integrative Physiological and Behavioral Science •••••: •••••
••••• •••••, J. (•••••). Eetbuien als aangeleerd gedrag. Voeding •••••: •••••
••••• Cummings, D.E., •••••, J, Foster-Schubert, K.E. (•••••). Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. Journal of Clinical Endocrinology Metabolism •••••: •••••
••••• Gelling, R.W., •••••, J., Morrison C.D., Morton G.J., Frayo, R.S., Cummings D.E., Schwartz MW (•••••). Effect of uncontrolled diabetes on plasma ghrelin concentrations and ghrelin-induced feeding. Endocrinology •••••: •••••
••••• •••••, J., Kaplan, J., Grill, H., Frayo, R.S., Cummings, D.E.(•••••). Role of the duodenum and macronutrient type in ghrelin regulation. Endocrinology •••••: •••••
••••• Cummings, D.E., Foster-Schubert, K.E., •••••, J. (•••••). Ghrelin and energy balance: Focus on current controversies. Current Drug Targets 6: •••••
••••• Cummings, D.E., •••••, J., Foster-Schubert, K.E. (•••••). Roles for ghrelin in the regulation of appetite and body weight. Current Opinion in Endocrinology and Diabetes •••••: •••••
••••• Cummings, D.E., •••••, J, Shannon, M.H., Foster-Schubert, K.E. (•••••). Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgery. Surgery for Obesity and Related Diseases 1: •••••


Book Chapters
••••• •••••, J. & Jansen A. (•••••) The conditioning model of binge eating. In: I. Florin & B. Tuschen (eds.). Current Research in Eating Disorders, ••••• ••••• Mnster: Verlag fr Psychotherapie
••••• Jansen, A., •••••, J. & Meijboom, A. (•••••). Controlled and automatic cognitive processes in eating disorders. In: I. Florin & B Tuschen (eds), Current Research in Eating Disorders, ••••• ••••• Mnster: Verlag fr Psychotherapie
••••• Cummings, D.E. & •••••, J. (•••••). Circulating ghrelin levels in pathophysiological conditions. In: E. Ghigo (ed.). Ghrelin. Kluwer Academic Publishers

MA Thesis
•••••, J. (•••••). Eye-blink reflex modification by movie-induced negative mood. MA Thesis, Faculty of Psychology, University of Amsterdam, The Netherlands

MSc Thesis
••••• J. (•••••). Conditioned Place Preference and Exploratory Behaviour in the Rat. MSc Thesis, School of Pharmacy, University of Bradford, United Kingdom

PhD Dissertation
••••• J. (•••••). Pavlovian Conditioning and Binge Eating. Doctoral dissertation, Dept. of Health Sciences, University of Maastricht. The Netherlands

Recent Abstracts (op oral presentation; p poster)
••••• •••••, J. Therapy for animals? Encouragement of exploratory behavior as a model of recovery from depression. Ethopharmacology Conference •••••, Neurobiology 5, ••••• (op)
••••• •••••, J & Reeve, J.R., Gibbs, J. Comparison of satiating actions of CCK••••• and CCK••••• SSIB conference ••••• (p)
••••• •••••, J, Hampton, L, Battey, J, Sanchez, N & Gibbs, J. Food intake in mice lacking bombesin receptor subtype••••• SSIB conference ••••• (p)
••••• Sanchez, P, •••••, J, Hampton, L, Battey, J., Henderson, R., & Gibbs, J. Hyperphagia of mice lacking the bombesin receptor subtype••••• is characterized by increased meal size and decreased meal number. SSIB conference ••••• (p)
••••• •••••, J, Frayo, R.S. & Cummings, D.E. Role of the duodenum and macronutrient type in prandial suppression of ghrelin. NAASO conf. ••••• Obesity Research ••••• suppl. A••••• (op)
••••• •••••, J, Frayo, RS, Baskin, D & Cummings, DE. A peripheral contribution to meal-related ghrelin suppression. Annual meeting of the Society for Neuroscience, ••••• (p)
••••• •••••, J, Tylee, T.S., Frayo, RS, & Cummings, D.E. Central insulin administration acutely suppresses plasma ghrelin levels in rats. American Diabetes Association, •••••th Scientific Sessions ••••• (op)

Book Reviews
••••• •••••, J. (•••••). Passie. Review of Dieptepsychologie van J.H. van den Berg. De Psycholoog •••••, •••••
••••• •••••, J. (•••••). De onvermoede wijsheid van een kwijlende hond. Review of B.R. Dworkin, Learning and Physiological Regulation. De Psycholoog •••••, ••••• •••••
••••• •••••, J. (•••••). Pavlov en de wijsheid van het lichaam. Review of B.R. Dworkin, Learning and Physiological Regulation. Amsterdams Boekenblad 9, ••••• •••••
••••• •••••, J. (•••••). Hulpeloosheid volgens de regels. Review of C. Peterson, S. Maier, M. Seligman, Learned Helplessness. De Psycholoog •••••, •••••
••••• •••••, J. (•••••). Modern dierenbewustzijn. Review of ••••• et al., Animal consciousness and animal ethics. De Psycholoog •••••, •••••
••••• •••••, J. (•••••). De minder bekende Pavlov. Review of Ivan Pavlov, De fysiologie van de spijsvertering, and Psychopathology and Psychiatry. De Psycholoog •••••, •••••